Regarding the strengths of this research, respondents were recruited by using an online research panel with stratified quota sampling to ensure that the sample would meet the characteristics of sex, age, household income of the Italian population. Moreover, the C19PRC Study was designed drawing from studies that investigated previous IRDs epidemics and their psychosocial impact (e.g., H1N1, MERS, SARS). To do so, several factors were assessed to capture the complexity of the phenomenon from an ecological perspective, taking into account the demographic, social, political, economic, and psychological influences. The findings of this project may be useful to understand and manage the psycho-social implications of the COVID-19 pandemic.