Kuipers et al. reported the case of a 56-year-old Afro-Caribbean man with a medical history of type 2 diabetes presenting to the emergency department with myalgia, dry cough and a peripheral O2 saturation (SpO2) of 94%, but not fever. COVID-19 was confirmed by a positive SARS-CoV-2 PCR test result. Bilateral ground glass opacities of the chest were detected by CT. In the following days, an increasing need for O2 administration was noted, SpO2 dropped to 83% and mechanical ventilation was initiated as well as treatment with chloroquine. Twelve hours later, hemolysis and an abnormally high level of MetHb (9.1%) were noted (Figure 2a). The patient was then treated with three units of packed red blood cells in the following 48 h and ascorbic acid (vitamin C) intravenously four times a day for two days, resulting in a normalization of MetHb levels within six days. A suspected glucose-6-phospate dehydrogenase (G6PD) deficiency was confirmed by genetic analysis.