Figure 4.  Representation of the MD analysis plots for the RMSD matrix cluster formation showing number of clusters in (A) spike protein, (B) spike-rutin complex, (C) main protease, and (D) main protease-rutin complex. The most dominant cluster conformation after MD cluster analysis of (E) spike protein, (F) spike-rutin complex, (G) main protease and (H) main protease-rutin complex.