Main protease + rutin Interacting residue H-bond distance (Å) H-bond (D-H--A) Hydrophobic residues THR 26.A O–Rutin.het O15 3.05 HO-H--O15 Thr25, Leu27, His41, Met49, Gly143, His164, THR 26.A O–Rutin.het O16 3.02 HO-H--O16 Met165, Leu167, Pro168, Arg188, TYR 54.A OH–Rutin.het O14 2.91 HOH-H--O14 Gln189 ASN 142.A OD1–Rutin.het O5 3.01 HOD1-H--O5   ASN 142.A OD1–Rutin.het O7 2.91 HOD1-H--O7   GLU 166.A O–Rutin.het O8 3.02 HO-H--O8   ASP 187.A O–Rutin.het O14 3.31 HO-H--O14   THR 190.A O–Rutin.het O10 2.87 HO-H--O10