At present, there are no regulatory approved drugs for treatment of COVID-19. Current recommendations include supportive care, ventilator based assistance for respiration, usage of anti-infectives, antivirals, and glucocorticoid therapy [39]. National Health Commission of the People’s Republic of China has provided some preferred drugs for treatment of COVID-19 that include interferon alpha, lopinavir/ritonavir, chloroquine phosphate, ribavirin, and arbidol. Some of the drugs that are presently at clinical trials stage are chloroquine, arbidol, remdesivir, and favipiravir [40,41]. Of all these drugs lopinavir/ritonavir, chloroquine phosphate, and arbidol are administered via oral route. However, favipiravir appears to be the most potent and promising drug when compared to lopinavir/ritonavir. In India, Glenmark Pharmaceuticals has initiated phase III clinical trials for favipiravir and is expected to complete the trials by end of August 2020 [42]. The solubility of this drug is very poor in water and is necessary to convert it into its salt version (sodium or meglumine) and formulate it as an injection. A Chinese company by name Chengdu Xinhengchuang Pharmaceutical Co., Ltd. developed a tablet formulation that helps in overcoming the dissolution problem and achieved desired clinical results [43]. Table 1 provides a list of antiviral agents that are currently being developed by various investigators in the world for treating COVID-19. From the table, it is evident that researchers focus is on both small molecules [55] and biologics [45,46, 48]. Further, proteins such as brilacidin [44] and recombinant protein AT-100 [50] are being developed by Innovation Pharmaceuticals and Airway Therapeutics, respectively.