ODFs are excellent and attractive carriers for delivery of various over the counter (OTC) or prescription drugs [17], herbal extracts [18–21], vaccines [22], probiotics [23], and vitamins [24]. Drugs are either directly introduced [25–28] in the formulation of ODFs or size reduced and converted to solid dispersions [29] or nanoparticles [30,31] or solid lipid microparticles [32] or micronized and surface modified using silica [33] which not only help in enhancing the amount of drug that could be loaded on to ODFs but also help in enhancing the release rate and, bioavailability of the drug. At present, ODFs are used as an excellent carrier system for delivering various therapeutically active agents. The composition of ODFs includes a drug substance (natural or synthetic), a film-forming agent and plasticizer. Additionally, it also includes saliva stimulating agent, organoleptic agents, and stabilizers [12]. The critical quality characteristics of ODFs are its appearance, stability, water content, uniformity of the active agent, color, taste, aftertaste, and mouthfeel. Most importantly, it shall not cause irritation of mucosa when administered [34]. The authors provided an overview on characterization of ODFs to determine various quality parameters of ODFs and also introduced a 3D printed disintegration test apparatus for testing the disintegration time of ODFs using sensor technology [35]. ODFs are capable for drug delivery in patients with swallowing problems, mentally retarded patients, subjects with Parkinson’s disease, bed-ridden patients, oral cancer patients, and uncooperative patients [36–38]. The present review is focused on critically analyzing the potential of ODFs as carriers for delivering antiviral drugs/herbs/vaccines with a potential for treatment of COVID-19, the global pandemic.