d are usually swallowed along with saliva and a small amount of the drug gets absorbed via the oral mucosa due to its high vasculature [15,16]. ODFs are excellent and attractive carriers for delivery of various over the counter (OTC) or prescription drugs [17], herbal extracts [18–21], vaccines [22], probiotics [23], and vitamins [24]. Drugs are either directly introduced [25–28] in the formulation of ODFs or size reduced a