While the research is going on to identify an active agent for COVID-19. Identifying the mode of delivering the active moieties to patients and healthy subjects cannot be ignored. At present, there are several drug delivery systems, whereas the most novel and transformative drug delivery/carrier system is orodispersible films (ODFs). European Pharmacopoeia (Ph. Eur.) defines ODFs as ‘single or multilayered sheets of suitable materials, to be placed in the mouth where they disperse rapidly’ [11]. They are a type of oromucosal preparations which are ultra-thin, elegant, stamp sized, portable, patient friendly, and attractive dosage forms across all the age groups [12]. Clinical Data Interchange Standards Consortium (CDISC) defines ODFs as ‘A thin layer or coating which is susceptible to being dissolved when in contact with a liquid’ [13]. On the contrary, United States Pharmacopoeia (USP) employs a different terminology and called them as ‘Oral Films’ and defined as ‘Thin sheets that are placed in the oral cavity. They contain one or more layers. A layer might or might not contain API’ [14]. ODFs undergo rapid disintegration/dissolution and are usually swallowed along with saliva and a small amount of the drug gets absorbed via the oral mucosa due to its high vasculature [15,16].