Primarily, vaccines pose extreme challenges vis-a-vis its handling, (cold) storage and shipping, all expensive propositions. For instance, one of the studies reported that 38 billion USD would be spent on transportation and administration of 18 vaccines in 94 countries [123,124]. Therefore, there is a need for alternate dosage forms that can help reducing the cost. For instance, Vaxart Inc is developing recombinant vaccine for COVID-19 in tablet formulation using its patent protected technology called VAAST [107–109]. RP Scherer Technologies LLC is also developing a tablet formulation (fast dissolving) for influenza vaccine with starch as immune stimulating agent [125]. Tablets are highly traditional and conventional dosage forms that are difficult to administer to patients who have dysphagia or Parkinson’s disease and are extremely difficult to administer to pediatrics and geriatrics. Therefore, ODFs remain as an alternate choice of administration as they do not need water to consume. Most importantly, they are easy to transport from one place to another. Israel’s Migal Galilee Research Institute is actively developing a vaccine that is administered via oromucosal route [104]. Some of the vaccine preparations that are successfully formulated as ODFs are provided in Table 6.