It is beyond any doubt that we have to adhere to the infection prevention practices against COVID-19 till an effective and safe vaccine becomes available to the general public. Our study shows that it is not the socio-demographic factors but the lack of preventive practices that are statistically associated with the development of the disease among the attendees of a COVID-19 clinic in an urban setting. The social distancing of more than six feet, maintaining hand hygiene at frequent intervals, and ensuring N-95 mask fitness were three major practices that showed protection against the disease when analyzed statistically. Pre-exposure prophylaxis with hydroxychloroquine did not show any protective role, and the prophylactic role of the alternative medicines against COVID-19 is unclear in this study. Finally, the preventive practices go hand in hand with the awareness against the disease, and they are only effective when followed in every aspect of our lives. Adherence to these practices is still not satisfactory; thus, behavioral modifications are required in the general public's day-to-day lives to follow preventive practices consistently.