Herein, we briefly describe each known SPMs receptors (Fig. 2). Previous studies have demonstrated that pro-resolving activities of SPMs occur through activation of one or more G protein-coupled receptors (GPCRs), suitable receptors for several types of SPMs have not yet been identified. Four GPCRs have been reported as receptors for RvD1 and RvE1; however, it has not been determined whether other Rvs and PDs such as RvE2, RvE4, RvD2, RvD3, PDs, and MaRs act on these GPCRs (Arita et al. 2005, 2007; Krishnamoorthy et al. 2010). For recent and specific physiological actions of these receptors and research data in KO mice, we would like to refer to other reviews and references there (Park et al. 2020; Im 2012).