Conclusions
New evidence suggests that more severe presentations associated with COVID-19 are emerging in pediatric patients, MIS-C, which can present with a prolonged history of fever, along with other criteria. In cases where children present with prolonged fever of unknown origin, they should continue to receive a workup for sepsis in addition to considering COVID-19 infection during this pandemic. MIS-C should be also be considered as a possibility. Cheilitis may be a new sign or clinical manifestation of COVID-19. Although the occurrence of cheilitis has not been well described in the current COVID-19 literature, more research is needed to investigate this finding.