As of April 2020, the World Health Organization (WHO) noted that 80% of confirmed COVID-19 positive pediatric patients displayed mild symptoms such as fever, non-productive cough, and fatigue and often recovered without requiring hospitalization [11]. This patient presented with fever without an apparent source prompting a partial workup for sepsis. The patient required hospitalization for continued diagnostic workup and empiric treatment. This patient did not develop any respiratory complications from his COVID-19 infection. It is important to now consider COVID-19 as a potential differential diagnosis in addition to routine sepsis workup in pediatric patients presenting with persistent fever without a defined source of infection. Occult infectious etiologies such as bacteremia, urinary tract infection, and meningitis, should not be discounted for patients with persistent fever. Acute cheilitis may be another manifestation of COVID-19, and the occurrence of this finding in febrile children should raise the suspicion of COVID- 19. We suggest testing for COVID-19 for febrile children presenting with cheilitis that is otherwise unexplained.