Different factors or comorbidities that may influence the development of headache have been described in the literature.30 If we look at risk markers, age and sex deserve special attention. The female sex is closely related to the development of ‘de novo’ headache.31 Age is a determining factor in the classification of headache according to the International Headache Society.11 Several studies have shown that pain intensity,32 the degree of headache disability and the possibility of secondary headache occurrence are age-related factors.33 In terms of other individually modifiable risk factors, the relationship between blood pressure changes and primary headache should be highlighted, as they share mechanisms of action such as vascular endothelial dysfunction or poor cardiovascular autonomic regulation.34 However, in our study we did not find a clear association between different comorbidities of the individual and the appearance of headache, except for tobacco consumption in the univariate analysis.