Table 1 Baseline conditions and mask and Personal Protective Equipment (PPE) usage among healthcare workers Total De novo headache P value No Yes N= 261 (n=103) (n=158) Age, years (SD) 42.9 (10.7) 40.8 (11.4) 44.4 (10.1) 0.009 Female gender 208 (79.7%) 73 (31.1%) 135 (64.9%) 0.004 Occupation 0.0001  Doctor 112 (42.9%) 61(54.5%) 51 (45.5%)  Nurse 95 (36.4%) 33 (34.7%) 62(65.3%)  Others 54 (20.7%) 9(16.7%) 45(83.3%) Work shift <0.0001  Mornings and 24-hour duties 89 (34.1%) 51 (57.3%) 38 (42.7%)  Rotating shifts 91 (34.9%) 26 (28.6%) 65 (71.4%)  Others 81 (31.0%) 26 (32.1%) 55 (67.9%) Type of face mask 0.029  Surgical mask 208 (79.7%) 89 (42.8%) 119 (57.2%)  N95/FFP2 53 (20.3%) 14 (26.4%) 39 (73.6%) Number of hours worn per day (SD) 6.9 (2.3) 6.8 (2.4) 7.0 (2.2) 0.474 Use of another PPE: 0.203  Face shield 54 (20.7%) 21 (38.9%) 33 (61.1%)  Protective eyewear 33 (12.6%) 13 (39.4%) 20 (60.6%)  Complete PPE 46 (17.6%) 16 (34.8%) 30 (65.2%) Confirmed COVID-19 12 (4.6%) 4 (33.3%) 8 (66.7%) 0.161 Pre-existing headache 110 (42.1%) 45 (40.9%) 65 (59.1%) 0.683 Comorbidity  Allergy 34 (13.0%) 16 (47.1%) 18(52.9%) 0.331  Asthma 17 (6.5%) 11 (64.7%) 6 (35.3%) 0.028  Tobacco 41 (15.7%) 8 (19.5%) 33 (80.5%) 0.004  Arterial hypertension 18 (6.9%) 9 (50.0%) 9 (50.0%) 0.789  Cardiopathy 1 (0.4%) 0 (0.0%) 1 (100%) 0.419  Dyslipidaemia 14 (5.4%) 7 (50.0%) 7 (50.0%) 0.76  Diabetes 2 (0.8%) 1 (50.0%) 1 (50.0%) 0.76  Thyroid disease 28 (10.7%) 9 (32.1%) 19 (67.9%) 0.402  Anxiety 26 (10.0%) 6 (23.1%) 20 (76.9%) 0.072  Others 16 (6.1%) 4 (25.0%) 12 (75.0%) 0.222 Other symptoms  Sleep disturbance 79 (30.3%) 11 (13.9%) 68 (86.1%) 0.0001  Loss of concentration 73 (28.0%) 14 (19.2%) 59 (80.8%) 0.0001  Irritability 74 (28.4%) 18 (24.3%) 56 (75.7%) 0.002  Photophobia 31 (11.9%) 8 (25.8%) 23 (74.2%) 0.097  Sonophobia 24 (9.2%) 6 (25.0%) 18 75.0%) 0.128  Sickness/vomiting 24 (9.2%) 11 (45.8%) 13 (54.2%) 0.503 FFP2, filtering face pieces; N95, 95% particle filtering capacity.