1, Phe140,Glu166, Ser144,His172,Met165, His164, Gln189, Asp187, Arg188, Met49, His41  –76.27  –67.75  –8.52  0  Thr25, Thr26, Leu27, Cys145, His163, Met165, Glu166,His172, Phe140, Leu141,Ser144, Gly143   
9.  Withasomnine  –5.22  149.2 µM  Ser158, Ile152, Asp153, Asn151, Thr111, Asp295, Phe294, Thr292, Gln110  –6.2  28.68 µM  Ile152, Phe8, Val104, Ile106, Gln110, Thr111, Asn151, Asp153, Phe294  –71.96  –60.03  –11.94  0  His41, His163,