4.  Withanolide D  –7.68  2.34 µM  Gly182, Tyr184, Glu185, Ser189, Met190, Gln191, Leu192, Glu193  –9.3  145.58 nM  Glu54, Asn52, Tyr53, Arg40, Tyr81, Met57, Gln132, Ser131, Arg80, Val197, Thr239, Gly83  –111.44  –98.83  –12.61  0  Gly154, Asn153, Leu151, Glu152, Gln8, Gly122, Ser123,Cys116, Tyr117, Ala115, Thr143, Ile140, Ser138, Gln295, Met6, Arg294