6.  Withanone  –9.09  218.4 nM   Val159, Gly160, Glu161, Asn109, Leu162, Gln269, Gln269  –10.1  38.83 nM  Trp106, Glu167, Ala107, Trp93, Lys92, His89, Asp108, Lys157, Asp164, Tyr264, Gly163, Tyr273, Val165, Thr301, Pro248  –109.36  –87.06  –22.31  0  Asn109, Thr158, Gly160, Gln269,Glu161, Leu162, Val159,His89