2.  Withanolide A  –10.19  34.04 nM   Gln269, Asn109, Leu162, Glu161, Gly160, Val159, Thr158  –10.2  32.78 nM  Asp286, Asn267, Asp164, Tyr264, Tyr273, Pro248, Gly163, Leu162, Lys157, Asp108, Ala107, Trp106, Gly266, Ala288, Lys105, Tyr268, Leu289  –103.61  –84.71  –18.90  0   Asn109, Val159, Thr158, Glu161, Gly160, Gln269, Leu162