8.6  447.56 nM  Gln218, Phe59, Gly219, Phe220, Thr33, Asp287, Phe58, Val289, Ser297, Lys300, Asp294, Leu296, Asn606, Leu293  –84.45  –66.52  17.93  0  Thr430, Asp428, Phe515, Ser514, Glu516