a754, Asp757, Arg761, Leu846, Arg758, Pro651, Ile652, Leu843, Leu597, Gln599, Ala633, Val581, Tyr300, Thr302  –104.25  –83.69  –20.56  0  Arg453, Glu452, Asp454, Ser456, Arg449, Arg441, Val458, Pro459, Arg444, His445, Phe460, Pro466, Gly464, Ser461, Lys465   
2.  Withanolide A  –9.78  67.23 nM  Gln984,Leu983, Thr980, Gly981, Arg977, Phe952, Tyr738  –10.5  19.50 nM  Ile299, Ala754, Ser750, Thr302, Ala753, Val581, Leu843,