Withasomnine  –4.99  218.08 µM  Tyr523, His513, Val380, His383, Glu384, His387, Ala356, Ser355, Ala354, His353  –6.7  12.59 µM  Phe291, Tyr394, His410, Arg522, Gly404, Pro407, Glu403, Met223, Phe570, Asn406  –74.24  –64.10  –10.14  0  Leu122, Thr92, Ala125, Arg124, Ala89, Ile88, Asn85, Asn136, Trp59