Ligands  Human intestinal absorption (HIA)  Caco-2 permeability  P-glycoprotein inhibitor  Blood–brain barrier penetration (BBB)  Ames mutagenesis  Subcellular localization  Biodegradation  Acute oral toxicity (kg/mol)
±  p value  ±  p value  ±  p value  ±  p value  ±  p value  ±  p value  ±  p value
Withaferin A  +  0.9729  –  0.6673  +  0.6132  +  0.9537  –  0.6900  Mitochondria  0.7714  –  0.8750  3.276
Withanolide A  +  0.9829  –  0.6006  +  0.6554  +  0.8333  –  0.8700  Mitochondria  0.6830  –  0.8000  5.165
Withanolide B  +  0.9829  –  0.5605  +  0.7494  +  0.9128  –  0.8000  Mitochondria  0.6784  –  0.8750  4.099
Withanolide D  +  0.9750  –  0.6274  –  0.4303  +  0.8345  –  0.7800  Mitochondria  0.7352  –  0.8250  3.66
Withanolide E  +  0.9640  –  0.6455  –  0.4399  –  0.5510  –  0.7100  Mitochondria  0.6273  –  0.9250  5.292
Withanone  +  0.9829  –  0.6472  +  0.6845  +  0.8333  –  0.8300  Mitochondria  0.6830  –  0.8500  4.775
Viscosalactone B  +  0.9480  –  0.7386  –  0.4906  +  0.9214  –  0.7500  Mitochondria  0.7598  –  0.8250  3.059
Anaferine  +  0.9064  +  0.5418  –  0.9112  +  0.9929  –  0.7300  Mitochondria  0.7672  –  0.7000  2.517
Withasomnine  +  0.9932  +  0.9586  –  0.9813  +  0.9966  –  0.9100  Mitochondria  0.5372  –  0.8750  2.41
Losartan  +  0.9883  –  0.9373  +  0.8124  –  0.9930  –  0.5200  Mitochondria  0.7540  –  0.9250  3.322
Procainamide  +  0.9795  +  0.9185  –  0.9721  +  0.9707  –  0.5900  Lysosomes  0.8295  –  0.6000  2.59
Cinacalcet  +  0.9911  +  0.7035  +  0.5803  +  0.9974  –  0.5000  Lysosomes  0.9070  –  1.0000  3.492
Arbidol  +  0.9684  +  0.6814  +  0.6810  +  0.9739  +  0.5300  Lysosomes  0.5338  –  0.9000  2.753
Hydroxychloroquine  +  0.9934  +  0.5313  –  0.7900  +  0.9878  +  0.6400  Lysosomes  0.8067  –  0.8500  2.665
Oberadilol  +  0.9820  –  0.7895  +  0.7739  +  0.9693  –  0.6300  Mitochondria  0.8157  –  0.7250  3.747
Poziotinib  +  0.9852  –  0.6765  +  0.8852  +  0.9900  –  0.5600  Mitochondria  0.5163  –  0.9000  3.121