st of the FDA-approved drugs are known to be metabolized by a ubiquitous protein family of heme-thiolate enzymes known as cytochrome P450s (CYPs). Regioselectivity-WebPredictor (http://reccr.chem.rpi.edu/Software/RS-WebPredicto/) is an algorithm for accurate prediction of isozyme-specific cytochrome P450 (CYP)-mediated sites of metabolism (SOM) on drug like molecules (Neb