1975; Mortelmans & Zeiger, 2000). Mutagenic effects bear a close connection to carcinogenesis (Xu et al., 2012). Interestingly, in the present study, none of the chosen WS phytoconstituents were predicted to have any mutagenic effect. The 3CL-pro of CoVs is necessary for the proteolytic maturation of the virus and a potential drug