Along with increased IgG and IgA levels, severe cases also had an increased number of antibody-secreting cells and TFH cells, which aid in antibody production. Further, a close correlation of proinflammatory cytokines and chemokines like IL-6, CXCL10 and complement activation marker C5a found with the severe disease condition. This study provided a direct relation of inflammatory response with humoral immune response in context to the disease severity. However, the antigen-neutralizing property of these SARS-CoV-2 specific antibodies was not determined. Further, a low sample size of severe cases was another limiting factor to provide a definitive conclusion that robust antibody response may positively correlate with disease severity.