While across studies, it has become apparent that T cells show robust activation status in severe cases than mild and moderate. These cells also exhibit exhaustion status, which may occur concomitantly with their activation status. Deep immune profiling of 125 patients by Mathew et al. (2020) demonstrated that both CD4+ and CD8+ T cells exhibit activation status as revealed by coexpression of CD38 and HLA-DR which corresponded to the disease severity. Further, these cells were also associated with concomitant expression of proliferation (Ki-67) and exhaustion (PD-1) markers. This study thus suggests that hyperactivated status of T cells may eventually lead to their exhaustion, and thus these functional and exhaustion features of T cells may reflect the disease severity.