and ARDS in COVID-19 patients.

Innate Nucleic Acid Sensing and Viral Evasion Mechanisms

Nucleic Acid Sensors in Antiviral Signaling
SARS-CoV-2, like its predecessor SARS-CoV, employs spike (S) protein to enter into the eukaryotic cells by binding to the surface-expressed ACE2 receptors. Upon binding, S protein priming takes place by the membrane expresse