response in HEK293 cells and found these proteins inhibit IFN-β and NF-κB signaling. Similarly, Yuen et al. (2020) showed that IFN antagonizing effect of ORF6 was due to its association with the interferon-inducible nuclear export complex (NUP98–RAE1). The study further showed that Nsp13, Nsp14, and Nsp15 could also ant