red probable ATP-dependent RNA helicase DHX58 (also known as LGP2) (Jiang et al., 2011; Leiva-Juárez et al., 2018). RIG-I binds to 5’-PPP RNA and short dsRNA, while MDA5 binds to longer RNA fragments (Huang et al., 2014). Binding of pathogenic RNAs induces conformational changes in RIG-I and MDA5, and after that post-translational modifications activat