A range of SARS-CoV specific antibodies have shown cross-reactivity with SARS-CoV-2. These antibodies target S protein and mostly the RBD region (Hoffmann et al., 2020). Monoclonal antibodies against SARS-CoV such as CR3022 and S309 have shown cross-reactivity with SARS-CoV-2 (Pinto et al., 2020; Wang et al., 2020a). Similarly, in a study of 285 patients, S protein-specific antibodies from SARS-CoV showed cross-reactivity with CoV-2 N protein in a subset of patients (n = 5), whereas no-cross reactivity was detected against S1 subunit of SARS-CoV-2 (Long et al., 2020a). Thus, the cross-reactive nature of some of these antibodies may ensure their efficacy against multiple coronaviruses.