Further, a comparison of various disease states with corresponding antibody response will provide clearer insight as to how this response is regulated. It appears that in patients with severe disease symptoms, TNF-α may influence the GC and hence B cell number (Kaneko et al., 2020), whether the same holds for asymptomatic patients with compromised antibody durability remains elusive. This dynamic antibody response is critical while considering convalescent plasma therapy (CPT) for severe or critically ill patients. If a patient already has sufficient antibodies, CPT may not be a viable treatment option (Anderson et al., 2020; Duan et al., 2020). While many studies have reported success with CPT, some studies have shown no added beneficial effects with this approach (Li L. et al., 2020). Thus, pre-caution should be taken while using this approach, i.e., if a patient already has adequate virus-specific antibodies or presence of cross-reactive and auto-antibodies, plasma therapy may do more harm than good, which may be the reason with non-responsiveness of CPT in some patients (Nagoba et al., 2020).