Aerosol, droplet, and fomite transmission are important routes for the spread of many viral diseases, such as influenza and measles [10]. Viruses can be released from an infected individual or natural sources in aerosols (microscopic droplets small enough to remain airborne for minutes or more) and droplets (larger droplets that quickly deposit onto surfaces). Natural sources of viruses in aerosols and droplets include, for example, seawater [11] and wastewater systems [12]. Aerosols and droplets are complex systems due to their varying size, high surface-to-volume ratio, and spatially heterogeneous composition. Viruses that are immersed in aerosols and droplets experience a dynamic and highly variable microenvironment as aerosols and droplets evaporate and equilibrate with ambient environmental conditions, as illustrated in Fig 1; changes in the microenvironment may affect the viruses’ viability [13].