PMC:7712180 / 38845-39233 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7712180","sourcedb":"PMC","sourceid":"7712180","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7712180","text":"Substitutions of N27 having an H-bond with OA9 of the 9-O-acetyl carbonyl group, K81 forming H-bonds with O1 and N5 of Sia, or S83 containing an H-bond with O3 of Sia C1, with alanine and mutations of L80, L86 or W90 in hydrophobic pockets accommodating the 5-N-acyl moiety and the 9-O-acetyl-methyl moiety provided a mutant HCoV-OC43 S1A that had lost the ability to bind to 9-O-Ac-6SLN.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"1314","span":{"begin":81,"end":84},"obj":"Gene"},{"id":"1317","span":{"begin":325,"end":334},"obj":"Species"},{"id":"1326","span":{"begin":163,"end":169},"obj":"Disease"}],"attributes":[{"id":"A1314","pred":"tao:has_database_id","subj":"1314","obj":"Gene:3887"},{"id":"A1317","pred":"tao:has_database_id","subj":"1317","obj":"Tax:31631"},{"id":"A1326","pred":"tao:has_database_id","subj":"1326","obj":"MESH:C565170"},{"subj":"1314","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1317","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1326","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T219","span":{"begin":0,"end":388},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T219","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ecec93","default":true},{"id":"LitCovid-sentences","color":"#d293ec"}]}]}}