Receptor binding analysis of C/Johannesburg/1/66 classified in C/Aichi lineage [71] on a sialoglycan microarray showed that the virus predominantly binds to Neu5,9Ac2α2,6Galβ1,4GlcNAc β1,2Manα3(Neu5,9Ac2α2,6Galβ1,4GlcNAcβ1,2Manα6)Manβ1,4GlcNAcβ1,4GlcNAcitol-AEAB [72]. Further studies by using ICVs from other lineages may help to clarify whether receptor binding specificity of all ICVs to Neu5,9Ac2 depends on the α2,6 linkage or not.