3.4. Methodological Quality Assessment
The risk of bias and the quality of the preclinical and clinical investigations were assessed independently by the authors, using a checklist adapted from Cochrane Handbook for Systematic Reviews of Interventions, specifically adjusted for animal intervention study (SYRCLE’s) [171,172] and clinical trials [97]. The evaluation of the selected studies’ methodological quality was based on the presence or absence of information regarding the main objectives and findings, randomization of the treatment allocation, blinded drug administration, blinded outcome assessment and outcome measurements, as reported in Table 3 and Table 4. Only studies that reported a positive judgment in all considered parameters were assessed to be of a higher methodological quality. In contrast, the studies that did not wholly fulfil the criteria were included in the medium risk of bias, while those that completely lacked this information were deemed to be at high risk of bias.