Further, HCQ antiviral activity is also related to its anti-inflammatory and immunomodulatory effects. Different studies have, indeed, demonstrated that viral diseases are caused by a direct viral infection of susceptible cells and also by an impact on the immune response with consequent uncontrolled release of pro-inflammatory chemokines, cytokines, and other mediators [13]. The most studied antiviral activity of HCQ is that exerted against HIV; however, the current spread of the Coronavirus infection has brought attention back to this drug.