HCQ remains a worthwhile primary or additional therapy in lupus patients, considering the low cost and its safety profile, also in pregnancy. A randomized double-blind study reported the safety of HCQ during pregnancy, correlating this drug with less disease activity and a lower required dose of prednisone [93]. A 5-year prospective study evaluated the effect of HCQ discontinuation on lupus progression in pregnant women. As it occurs in no pregnant people, interruption of HCQ treatment is linked to an exacerbation of the disease. Moreover, there are no statistically significant differences regarding pregnant complications with respect to the control, showing no fetal toxicity at a dose of 6.5 mg/kg/day in breast milk [94]. Fetal safety has been also assessed in women with lupus nephritis by a multicenter study, reporting a reduction of 85% of the possibility of having a small for gestational age baby in patients under HCQ. Moreover, it exerted protective effects on fetal growth [120].