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PMC:7696151 / 37405-39261 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1102 957-965 Species denotes patients Tax:9606
1103 1066-1074 Species denotes patients Tax:9606
1104 1689-1697 Species denotes patients Tax:9606
1105 135-138 Chemical denotes HCQ MESH:D006886
1106 287-290 Chemical denotes HCQ MESH:D006886
1107 392-395 Chemical denotes HCQ MESH:D006886
1108 788-791 Chemical denotes HCQ MESH:D006886
1109 1059-1062 Chemical denotes HCQ MESH:D006886
1110 1186-1189 Chemical denotes HCQ MESH:D006886
1111 1477-1480 Chemical denotes HCQ MESH:D006886
1112 1603-1606 Chemical denotes HCQ MESH:D006886
1113 1759-1762 Chemical denotes HCQ MESH:D006886
1114 175-183 Disease denotes COVID-19 MESH:C000657245
1115 184-193 Disease denotes infection MESH:D007239
1116 422-430 Disease denotes COVID-19 MESH:C000657245
1117 578-586 Disease denotes COVID-19 MESH:C000657245
1118 650-664 Disease denotes tumor necrosis MESH:D009336
1119 713-725 Disease denotes septic shock MESH:D012772
1120 730-752 Disease denotes multiple organ failure MESH:D009102
1121 757-786 Disease denotes hepatic and renal dysfunction MESH:D008107
1122 894-900 Disease denotes Sepsis MESH:D018805
1123 942-956 Disease denotes critically ill MESH:D016638
1124 971-979 Disease denotes COVID-19 MESH:C000657245
1125 1354-1362 Disease denotes Covid-19 MESH:C000657245
1126 1417-1425 Disease denotes COVID-19 MESH:C000657245
1127 1654-1663 Disease denotes mortality MESH:D003643
1128 1680-1688 Disease denotes COVID-19 MESH:C000657245
1129 1842-1850 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T51 650-655 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T52 684-698 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T53 720-725 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T54 894-900 Phenotype denotes Sepsis http://purl.obolibrary.org/obo/HP_0100806

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T246 0-194 Sentence denotes In the light of collected data, despite the success of the first clinical trials, the latest studies have shown the ineffectiveness of HCQ for the treatment and prevention of COVID-19 infection.
T247 195-215 Sentence denotes So that, if the U.S.
T248 216-509 Sentence denotes Food and Drug Administration (FDA) had initially authorized the use of HCQ in case of emergency [61], in June 2020, the FDA revoked this authorization [62] since the potential HCQ effectiveness in treating COVID-19 was overtaken by severe cardiac adverse events and other serious side effects.
T249 510-753 Sentence denotes In fact, there is the need to consider that in subjects with severe COVID-19, the abundance of inflammatory molecules like interleukins and tumor necrosis factors generate a cytokine storm, leading to a septic shock and multiple organ failure.
T250 754-860 Sentence denotes In hepatic and renal dysfunction, HCQ metabolism and clearance were compromised and its safety is altered.
T251 861-1096 Sentence denotes Moreover, recently the Surviving Sepsis Campaign guidelines on the management of critically ill patients with COVID-19 concluded that there was insufficient evidence to recommend the routine use of HCQ in patients admitted in ICU [63].
T252 1097-1224 Sentence denotes In the same way, the American College of Physicians practice guidelines do not recommend HCQ for prophylaxis or treatment [64].
T253 1225-1485 Sentence denotes International trials like SOLIDARITY (International trial by World Health Organisation) [65], RECOVERY (Randomised Evaluation of Covid-19 Therapy) [66], and DISCOVERY (Trial of Treatments for COVID-19 in Hospitalized Adults) [67] have also stopped the HCQ arm.
T254 1486-1716 Sentence denotes In particular, the World Health Organisation (WHO), in the SOLIDARITY trial project, has arrested all arms involving HCQ, as evidence showed that it did not reduce the mortality of hospitalized COVID-19 patients compared with SOC.
T255 1717-1856 Sentence denotes However, this decision was not applied to HCQ use or evaluation in pre- or post-exposure prophylaxis for subjects exposed to COVID-19 [68].