Mahévas, et al. (2020) [39]  Observational comparativestudy181 severe COVID-19 infected patients  HCQ group -> 600 mg/day (n = 92)Control group -> SOC (n = 89)  On day 21:Overall survival was 89% in the HCQ group and 91% in the control group;survival without acute respiratory distress syndrome was 69% in the HCQ group and 74% in the control group;patients who had been weaned from oxygen was 82% in the HCQ group and 76% in the control group.