Molina et al. (2020) [34]  Prospective, non-comparative study11 severe COVID-19 infected patients  600 mg/day HCQ per 10 days + 500 mg AZM on day 1 followed by 250 mg/day for 4 days  On day 5 two patients were transferred to the ICU.At days 5 to 6, after treatment initiation 8 of 10 patients were still positive for SARS-CoV2 RNA.