Pandaya S. (2008) [29]  Uncontrolled clinical study305 patients with chronic CHIKV infection  15–20 mg/weekly MTX + 400 mg/day HCQ16 weeks  At 16th week a reduction in ACR score was shown  Not reported  There is not a control group. Only 114 subjects completed the study. It is not a blinded study and so the bias in reporting improvement could be present.