At the end of the 24th week, only the combination of drugs improved disease activity (mean ± SD DAS28; 3.39 ± 0.87 vs. 4.74 ± 0.65, p < 0.0001) and reduces disability (mean ± SD HAQ; 1.4 ± 0.31 vs. 1.8 ± 80.47, p < 0.0001) and pain (mean ± SD VAS 46 ± 6.13 vs. 60.8 ± 11.6, p < 0.0001).