Sperber, et al. (1997) [18]  Randomized, placebo-controlled clinical trial72 asymptomatic HIV-1 infected patients  800 mg/d HCQ (n = 35)500 mg/d ZDV (n = 37)16 weeks  After 16 weeks total plasma HIV-1 RNA levels were reduced in both ZDV group (42.709 ± 33.050 vs. 11.228 ± 7459 copies/mL; p = 0.001) and HCQ group (39.456 ± 31.000 vs. 16.434 ± 11.373 copies/mL; p = 0.02).No significant change occurred in CD4+ cellsOnly in HCQ group it was a reduction in the levels of IL-6 (12.4 ± 12.9 vs. 6.3 ± 5.4 U/nL; p = 0.03) and Ig-G (1453 ± 453 vs. 395 ± 544 mg/dL; p = 0.02)  Not reported.  Small sample-size. All of the patients were asymptomatic.