Data on patients with heart transplants in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) era are still limited and mostly anecdotal [3–13]. Immunosuppression-related issues present the main concern in this special population. An abnormal inflammatory response has been hypothesized to play a crucial role in acquiring severe forms of COVID-19, mainly due to damage of one's own tissues and microcirculatory thrombophilia [14]. Importantly, it is well established that severe infections in the immunocompromised population dramatically influence both the care and prognosis of patients.