The major limitations regarding our experience are related to the small size of the population studied. Months after the beginning of the pandemic, mounting evidence is emerging for therapy and supportive care practices for managing COVID-19 infections. More studies are needed to evaluate and correlate clinical and laboratory data to support our immunosuppressive modification strategy. The cohort of heart transplant recipients makes up a minimal part of the affected population and the need to collect patients in a multicentre study remains essential.