Our adopted therapeutic strategy resulted in one-third mortality in this particular population at risk of severe illness from infection with the SARS-CoV-2. One patient of advanced age with an already documented cardiac allograft vasculopathy did not overcome the disease, having developed a severe form. Available data show a higher mortality rate among older male patients with cardiovascular comorbidities who are infected with SARS-CoV-2. Furthermore, we must consider that during the outbreak the maximum standard of care was not achievable for all due to the limited availability of intensive care unit beds. The other death was the consequence of a complicated course of hospitalization for a patient not responsive to antibiotic therapy who developed sepsis. In addition, in 1 case we even managed to treat the infection at home in an unprecedented era in which healthcare resources are limited by the pandemic.