The vast majority of studies to date show impairment of proliferation, maturation, and response of T cells, especially in sicker patients. This may indicate that SARS-CoV-2, similarly to other viral infections, can interfere with the function of CD4+ cells at the very beginning of the infection, causing excessive release of inflammatory mediators and exhaustion of the response capacity of these cells over time, reducing the host’s antiviral immunity (189). What seems to happen in COVID-19 is that the total lymphocyte count is reduced in these patients and, among the remaining T cells, the highest percentage is from naïve CD4+ T lymphocytes, while the activated subpopulations, although few, present a phenotype with excess and reduced markers related to activation and function, respectively, indicating that, despite overactivation, these cells fail to exercise effective immune activity.