In addition, high levels of mediators, such as IL-6, TNF-, and IL-10, found in these patients are likely to have been produced by these monocytes and to be highly involved in cytokine storm and pathogenesis of SARS-CoV-2, since as the disease progresses these mediators reduce, which is correlated to the restoration of the immune function of CD4+ and CD8+ T lymphocytes, which is further discussed later (154).