On the other hand, in theory, a type I IFN-mediated response activates the JAK-STAT signaling pathway that should be able to suppress viral replication and prevent the virus from spreading early in the infection. This is probably what occurs in asymptomatic individuals who can establish an effective response against SARS-CoV-2 (9, 141). However, in several viruses, viral proteins can modulate the production of this type of IFN, impairing the generation of an effective antiviral response (141, 143, 146, 147). Li et al. (148) conducted an in vitro experiment that revealed a strong capacity of ORF6, ORF8, and nucleocapsid proteins of SARS-CoV-2 to inhibit IFN-β and NF-κB activity, in addition to genes containing interferon-stimulated response elements (ISREs), suggesting that the virus has an important IFN antagonist activity.